Современные представления о механизмах резистентности к антимикробным препаратам Enterococcus Faecalis и E. Faecium (обзор литературы)
Аннотация
В настоящее время энтерококки все чаще становятся этиологическими агентами разнообразных инфекционных патологий. Наиболее распространенными видами, вызывающими большинство энтерококковых инфекций являются Enterococcus faecalis и E. faecium. Оба вида демонстрируют природную низкоуровневую устойчивость к аминогликозидам, цефалоспоринам, хинолонам, клиндамицину и ко-тримоксазолу. Кроме того, особенности их генома позволяют легко приобретать резистентность к другим, широко используемым в клинической практике антибактериальным препаратам, посредством мутаций или путем горизонтального переноса генетических детерминант устойчивости. В обзоре изложены современные знания о механизмах резистентности энтерококков к наиболее часто используемым антибактериальным препаратам.
Ключевые слова
Об авторах
Татьяна Сергеевна КоменковаРоссия
аспирант Центральной научно-исследовательской лаборатории ФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава России (г. Владивосток, Россия)
Елена Александровна Зайцева
Россия
д.м.н., доцент, ведущий научный сотрудник Центральной научно-исследовательской лаборатории ФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава России (г. Владивосток, Россия)
Елена Александровна Зайцева
Россия
д.м.н., доцент, ведущий научный сотрудник Центральной научно-исследовательской лаборатории ФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава России (г. Владивосток, Россия)
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Коменкова Т.С., Зайцева Е.А., Зайцева Е.А. Современные представления о механизмах резистентности к антимикробным препаратам Enterococcus Faecalis и E. Faecium (обзор литературы). Антибиотики и Химиотерапия. 2020;65(11-12).
For citation:
Komenkova T.S., Zaitseva E.A., Zaitseva E.A. ACTUAL VIEW ON ENTEROCOCCUS FAECALIS AND E. FAECIUM RESISTANCE MECHANISMS TO ANTIBIOTICS (LITERATURE REVIEW). Antibiot Khimioter = Antibiotics and Chemotherapy. 2020;65(11-12).
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