The Development of a Turbidimetric Method for the Quantitative Determination of Antibiotics of the Aminoglycoside Group in Medications
https://doi.org/10.37489/0235-2990-2020-65-7-8-37-41
Abstract
A method for the quantitative determination of streptomycin sulfate in medicines by the turbidimetric method has been developedand validated. Based on the results of the experiments, it was found that the metrological characteristics of such validation parameters of the method as linearity, precision, and correctness do not exceed the validation criteria. Linearity was noted in the range of streptomycin concentrations from 3.75 to 8.43 μg/ml. The results of validation tests of the method for the quantitative determination of streptomycin indicate the prospects and feasibility of introducing the turbidimetric method into the domestic system for standardization and quality assessment of aminoglycoside antibiotics.
About the Authors
E. N. Semenova
Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
S. I. Kuleshova
Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
E. I. Sakanyan
Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Semenova E.N., Kuleshova S.I., Sakanyan E.I. The Development of a Turbidimetric Method for the Quantitative Determination of Antibiotics of the Aminoglycoside Group in Medications. Antibiot Khimioter = Antibiotics and Chemotherapy. 2020;65(7-8):37-41. (In Russ.) https://doi.org/10.37489/0235-2990-2020-65-7-8-37-41
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