Рифаксимин-альфа и другие кристаллические формы рифаксимина: есть ли отличия?

Рифаксимин - антибиотик, для которого характерен полиморфизм. У рифаксимина существуют различные кристаллические формы с разными фармакологическими характеристиками. Рифаксимин действует локально в пищеварительном тракте, поэтому важно, чтобы его абсорбция была минимальной, а концентрация в просвете кишечника высокой. Абсорбция в кишечнике других кристаллических форм рифаксимина более значима по сравнению с рифаксимином-α (Альфа Нормикс®). Различия в фармакокинетике кристаллических форм рифаксимина могут влиять на его эффективность и безопасность, особенно у пациентов с хроническими заболеваниями (состояние иммунодефицита и в условиях «leaky gut» на фоне цирроза печени), которым требуются длительные курсы терапии. Рифаксимин-α (Альфа Нормикс®) обладает уникальным действием, так как кроме местного антибактериального действия демонстрирует эубиотический эффект и обладает противовоспалительными свойствами. Учитывая разнообразные механизмы действия, рифаксимин-α положительным образом модулирует микробиоту кишечника.

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