Распространение генов mcr-типа, кодирующих устойчивость к полимиксинам, в России и мире
https://doi.org/10.37489/0235-2990-2021-66-1-2-57-64
Аннотация
В 2015 году впервые был описан ген устойчивости к полимиксинам mcr-типа, локализованный на мобильном генетическом элементе. После первого описания, последовали публикации, демонстрирующие глобальное распространение генов mcr-типа и роль животноводства в этом процессе. Одновременно, на фоне распространения генов приобретённой резистентности к карбапенемным антибиотикам, растёт практическое значение полимиксинов. Данный обзор кратко суммирует принципиальные данные, посвящённые данной проблеме.
Об авторах
В. А. АгеевецРоссия
Агеевец Владимир Андреевич — к. б. н.
Санкт-Петербург
И. В. Лазарева
Россия
Лазарева Ирина Владимировна — к. м. н.
Санкт-Петербург
О. С. Сулян
Россия
Сулян Офелия Спартаковна
Санкт-Петербург
А. А. Сухинин
Россия
Сухинин Александр Александрович
Санкт-Петербург
Список литературы
1. Benedict R.G., Langlykke A.F. Antibiotic activity of Bacillus polymyxa. J Bacteriol. 1947; 54 (1): 24.
2. Li J., Nation R.L., Turnidge J.D., Milne R.W., Coulthard K., Rayner C.R., Paterson D.L. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. Lancet Infect Dis. 2006. 6 (9): 589–601. doi: 10.1016/S1473-3099(06)70580-1.
3. Grayson M.L., Cosgrove S.E., Crowe S. et al. Kucers' the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs. Seventh edition. 2018; 5390. 4. Dixon R.A., Chopra I. Polymyxin B and polymyxin B nonapeptide alter cytoplasmic membrane permeability in Escherichia coli. J Antimicrob Chemother. 1986; 18 (5): 557–563. 5. Storm D.R., Rosenthal K.S., Swanson P.E. Polymyxin and related peptide antibiotics. Annu Rev Biochem. 1977; 46: 723–763.
4. Rhouma M., Beaudry F., Theriault W., Letellier A. Colistin in pig produc tion: chemistry, mechanism of antibacterial action, microbial resistance emergence, and one health perspectives. Front Microbiol. 2016; 7: 1789. doi: 10.3389/fmicb.2016.01789
5. Falagas M.E., Kasiakou S.K. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis. 2005; 40 (9): 1333–1341. doi: 10.1086/429323.
6. Biswas S., Brunel J-M., Dubus J-C. Reynaud-Gaubert M. Colistin: an up date on the antibiotic of the 21st century. Expert Rev Anti Infect Ther. 2012. 10 (8): 917–934. doi: 10.1586/eri.12.78
7. Olaitan A.O., Morand S., Rolain J.M. Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Front Microbiol. 2014; 5: 643.
8. Jayol A., Nordmann P., Brink A., Poirel L. Heteroresistance to colistin in Klebsiella pneumoniae associated with alterations in the PhoPQ regulatory system. Antimicrob Agents Chemother 2015; 59 (5): 2780–2784. doi: 10.1128/AAC.05055-14
9. Liu Y.Y., Wang Y., Walsh T.R. et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016; 16 (2): 161–168. doi: 10.1016/S1473-3099(15)00424-7
10. Shen Z., Wang Y., Shen Y. et al. Early emergence of mcr-1 in Escherichia coli from food-producing animals. Lancet Infect Dis. 2016; 16 (3): 293. doi: 10.1016/S1473-3099(16)00061-X
11. Poirel L., Nordmann P. Emerging plasmid-encoded colistin resistance: the animal world as the culprit? J Antimicrob Chemother. 2016; 71 (8): 2326–2327.
12. Kieffer N., Nordmann P., Poirel L. Moraxella species as potential sources of MCR-Like polymyxin resistance determinants. Antimicrob Agents Chemother. 2017. 61 (6): e00129–17. doi: 10.1128/AAC.00129-17
13. Poirel L., Kieffer N., Fernandez-Garayzabai J. et al. MCR-2-mediated plas mid-borne polymyxin resistance most likely originates from Moraxella pluranimalium. J Antimicrob Chemother. 2017; 72 (10): 2947–2949. doi: 10.1093/jac/dkx225
14. Eichhorn I., Feudi C., Wang Y. et al. Identification of novel variants of the colistin resistance gene mcr-3 in Aeromonas spp. from the national resistance monitoring programme GERM-Vet and from diagnostic submissions. J Antimicrob Chemother. 2018; 73 (5): 1217–1221. doi: 10.1093/jac/dkx538.
15. Carattoli A., Villa L., Feudi C. et al. Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016. Euro Surveill. 2017; 22 (31): 30589. doi: 10.2807/1560-7917.ES.2017.22.31.30589
16. Kieffer N., Royer G., Decousser J-W. et al. mcr-9, an inducible gene en coding an acquired phosphoethanolamine transferase in Escherichia coli, and its origin. Antimicrob Agents Chemother. 2019; 63 (9): e00965. doi: 10.1128/AAC.00965-19
17. Wang, C., Feng Yu, Liu L. et al. Identification of novel mobile colistin resistance gene mcr-10. Emerg Microbes Infect. 2020; 9 (1): 508–516. doi: 10.1080/22221751.2020.1732231
18. Xiaomin S., Yiming Y., Zhanggi S. et al. Global impact of mcr-1-positive Enterobacteriaceae bacteria on «one health». Crit Rev Microbiol 2020; 46 (5): 565–577. doi: 10.1080/1040841X.2020.1812510
19. Chiou C.S., Chen Y-T., Wang Y-W. et al. Dissemination of mcr-1-carrying plasmids among colistin-resistant salmonella strains from humans and food-producing animals in Taiwan. Antimicrob Agents Chemother 2017; 61 (7): e00338-17. doi: 10.1128/AAC.00338-17
20. Xavier B.B., Lammens C., Butaye P. et al. Complete sequence of an IncFII plasmid harbouring the colistin resistance gene mcr-1 isolated from Belgian pig farms. J Antimicrob Chemother 2016; 71 (8): 2342–2344. doi: 10.1093/jac/dkw191
21. Perreten, V., Strauss C., Collaud A., Gerber D. Colistin resistance gene mcr-1 in avian-pathogenic Escherichia coli in South Africa. Antimicrob Agents Chemother. 2016; 60 (7): 4414–4415. doi: 10.1128/AAC.00548-16
22. Meinersmann R.J., Ladely S.R., Plumblee J.R. et al. Prevalence of mcr-1 in the Cecal Contents of Food Animals in the United States. Antimicrob Agents Chemother. 2017; 61 (2): e02244-16. doi: 10.1128/AAC.02244-16
23. Sato T., Fukuda A., Usui M. et al. Isolation of a mcr-1-harbouring Escherichia coli isolate from a human clinical setting in Sapporo, Japan. J Glob Antimicrob Resist 2018; 13: 20–21. doi: 10.1016/j.jgar.2018.02.010
24. Huang H., Dong N., Shu L. et al. Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019. Emerg Microbes Infect. 2020; 9 (1): 237–245. doi: 10.1080/22221751.2020.1717380
25. Singh S., Pathak A., Kumar A. et al. Emergence of chromosome-borne colistin resistance gene mcr-1 in clinical isolates of Klebsiella pneumoniae from India. Antimicrob Agents Chemother. 2018; 62 (2): e01885-17. doi: 10.1128/AAC.01885-17
26. Eiamphungporn W., Yainoy S., Jumderm C. et al. Prevalence of the colistin resistance gene mcr-1 in colistin-resistant Escherichia coli and Klebsiella pneumoniae isolated from humans in Thailand. J Glob Antimicrob Resist 2018; 15: 32-35. doi: 10.1016/j.jgar.2018.06.007
27. Liakopoulos A., Mevius D.J., Olsen B., Bonnedahi J. The colistin resistance mcr-1 gene is going wild. J Antimicrob Chemother 2016; 71 (8): 2335–2336. doi: 10.1093/jac/dkw262
28. Ruzauskas M., Vaskeviciute L. Detection of the mcr-1 gene in Escherichia coli prevalent in the migratory bird species Larus argentatus. J Anti microb Chemother. 2016; 71 (8): 2333–2334.
29. Xiaomin S., Yiming L., Zhanggi S. et al. Global impact of mcr-1-positive Enterobacteriaceae bacteria on «one health». Crit Rev Microbiol. 2020; 46 (5): 565-577. doi: 10.1080/1040841X.2020.1812510
30. Ageevets V., Lazareva I., Mrudova T. et al. IncX4 plasmids harbouring mcr-1 genes: Further dissemination. J Glob Antimicrob Resist 2019; 18: 166-167. doi: 10.1016/j.jgar.2019.07.002
31. Sulian O., Ageevets V., Lazareva I. et al. Co-production of MCR-1 and NDM-1 by Escherichia coli sequence type 31 isolated from a newborn in Moscow, Russia. Int J Infect Dis. 2020; 101: 4–5. doi: 10.1016/j.ijid. 2020.09.1422
32. Xavier B.B., Lammens C., Ruhal R. et al. Identification of a novel plas mid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Bel gium, June 2016. Euro Surveill. 2016; 21 (27). doi: 10.2807/1560- 7917.ES.2016.21.27.30280
33. Ling Z., Yin W., Shen Z. et al. Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9. J Antimicrob Chemother. 2020; 75 (11): 3087–3095. doi: 10.1093/jac/dkaa205
34. AbuOun M., Stubberfield E., Duggett N.A. et al. mcr-1 and mcr-2 (mcr 6.1) variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015. J Antimicrob Chemother. 2018; 73 (10): 2904. doi: 10.1093/jac/dky272
35. Al-Kadmy I.M.S., Ibrahim S.A., Al-Saryi N. et al. Prevalence of Genes in volved in colistin resistance in acinetobacter baumannii: first report from Iraq. Microb Drug Resist. 2020; 26 (6): 616–622. doi: 10.1089/mdr.2019.0243
36. Zhang X., Zhang B., Wang J. et al. Colistin resistance prevalence in Esch erichia coli from domestic animals in intensive breeding farms of Jiangsu Province. Int J Food Microbiol. 2019; 291: 87–90. doi: 10.1016/j.ijfood micro.2018.11.013
37. Carretto E., Brovarone F., Nardini P. et al. Detection of mcr-4 positive Salmonella enterica serovar Typhimurium in clinical isolates of human origin, Italy, October to November 2016. Euro Surveill. 2018; 23 (2): 17–00821. doi: 10.2807/1560-7917.ES.2018.23.2.17-00821
38. Ma F., Shen C., Zheng X. et al. Identification of a novel plasmid carrying mcr-4.3 in an Acinetobacter baumannii strain in China. Antimicrob Agents Chemother. 2019; 63 (6): e00133-19. doi: 10.1128/AAC.00133-19
39. Borowiak M., Fischer J., Hammerl J.A. et al. Identification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B. J Antimicrob Chemother. 2017; 72 (12): 3317–3324. doi: 10.1093/jac/dkx327
40. Ma S., Sun C., Hulth A. et al. Mobile colistin resistance gene mcr-5 in porcine Aeromonas hydrophila. J Antimicrob Chemother. 2018; 73 (7): 1777-1780. doi: 10.1093/jac/dky110
41. Snesrud E., Maybank R., Kwak Y.I. et al. Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2018; 62 (8): e00679-18. doi: 10.1128/AAC.00679-18.
42. Partridge S.R., Pilato V.D., Doi Y. et al. Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes. J Antimicrob Chemother. 2018; 73 (10): 2625–2630. doi: 10.1093/jac/dky262
43. Yang Y.Q., Li Y-X., Lei C-W. et al. Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae. J Antimicrob Chemother. 2018; 73 (7): 1791-1795. doi: 10.1093/jac/dky111
44. Kneis D., Berendonk T.U., Hess S. High prevalence of colistin resistance genes in German municipal wastewater. Sci Total Environ. 2019; 694: 133454. doi: 10.1016/j.scitotenv.2019.07.260
45. Wang X., Wang Y., Zhou Y. et al. Emergence of a novel mobile colistin re sistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae. Emerg Microbes Infect. 2018; 7 (1): 122. doi: 10.1038/s41426-018-0124-z.
46. Kyany'a C., Musila L. Colistin resistance gene mcr-8 in a high-risk sequence type 15 Klebsiella pneumoniae isolate from Kenya. Microbiol Resour Announc. 2020; 9 (39): e00783-20. doi: 10.1128/MRA.00783-20.
47. Salloum T., Panossian B., Bitar I. et al. First report of plasmid-mediated colistin resistance mcr-8.1 gene from a clinical Klebsiella pneumoniae isolate from Lebanon. Antimicrob Resist Infect Control. 2020; 9 (1): 94. doi: 10.1186/s13756-020-00759-w
48. Carroll L.M., Gaballa A., Guldimann C. et al. Identification of novel mo bilized colistin resistance gene mcr-9 in a multidrug-resistant, colistin susceptible Salmonella enterica serotype typhimurium isolate. MBio, 2019; 10 (3): e00853-19. doi: 10.1128/mBio.00853-19
49. Li Y., Dai X., Zeng J. et al. Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9. Sci Rep. 2020; 10 (1): 8113. doi: 10.1038/s41598-020-65106-w.
50. Wise M.G., Estabrook M.A., Sahm D.F. et al. Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. PLoS One. 2018; 13 (4): e0195281. doi: 10.1371/journal.pone.0195281. eCollection 2018.
51. Klyasova G, Korobova A., Khrulnova S., Fedorova A., Vereschagina S., Molchanova I., Kutsevalova O. Detection of mcr-1 in Escherichia coli recovered from bloodstream infections in Russia: multicentre study. ECCMID 2018.
52. Tarabai H., Valcek A., Jamborova I. et al. Plasmid-mediated mcr-1 colistin resistance in Escherichia coli from a black kite in Russia. Antimicrob Agents Chemother. 2019; 63 (9): e01266-19. doi: 10.1128/AAC.01266-19
53. Azizov I., Eheck E., Sukhorukova M., Edelstein M. Plasmid-mediated resistance to coistin in clinical isolates of Klebsiella spp. and Escherichia coli: results of large retrospective surveillance in Russia. ECCMID P1413, 2019. doi:10.13140/RG.2.2.34812.59527
54. Скурихина Ю. Е., Туркутюков И.Б. Микробиологические и моле кулярно-генетические аспекты антибиотикорезистентности Pseu domonas aeruginosa и Acinetobacter baumannii. Эпидемиология и вакцинопрофилактика. 2019; 18 (6): 14–38. doi:10.31631/2073-3046- 2019-18-6-34-38
55. Sulian O., Ageevets V., Lazareva I. et al. Co-production of MCR-1 and NDM-1 by Escherichia coli sequence type 31 isolated from a newborn in Moscow, Russia. Int J Infect Dis 2020; 101: 4–5. doi: 10.1016/j.ijid.2020.09
56. Krylova E.V., Soltynskaya I., Bogomazova A., Pleskacheva M.A. Colistin resistance in escherichia coli isolatedfrom poultry in Russia. Journal of Infection and Public Health. 2020; 13 (2): 342. doi: 10.1016/j.jiph.2020.01.099
57. Sulian O., Ageevets V., Lazareva I., Sukhinin A., Sidorenko S. Occurrence of colistin resistance genes mcr-1 in livestock E.coli from in North-West of Russia. OHEJP ASM 2020 Abstracts book, 2020.
58. Слукин П.В., Светоч Э.А., Асланян Е.М., Асташкин Е.И., Ершова М.Г., Полетаева Е.Д., Шепелин А.П., Фурсова Н.К. Фенотипические и молекулярно-генетические свойства клинических штаммов Escherichia coli, выделенных от пациентов с урологическими заболеваниями. Урология, 2020. 2. OI: doi: 10.18565/urology.2020.2.23-30
Рецензия
Для цитирования:
Агеевец В.А., Лазарева И.В., Сулян О.С., Сухинин А.А. Распространение генов mcr-типа, кодирующих устойчивость к полимиксинам, в России и мире. Антибиотики и Химиотерапия. 2021;66(1-2):57-64. https://doi.org/10.37489/0235-2990-2021-66-1-2-57-64
For citation:
Ageevets V.A., Sulyan О.S., Lazareva I.V., Sukhinin A.A. Dissemination of MCR-Type Genes Encoding Polymyxin Resistance in Russia and Across the Globe. Antibiot Khimioter = Antibiotics and Chemotherapy. 2021;66(1-2):57-64. (In Russ.) https://doi.org/10.37489/0235-2990-2021-66-1-2-57-64