Preview

Antibiot Khimioter = Antibiotics and Chemotherapy

Advanced search

The Use of Antibacterial Drugs and Awareness About the Antibiotic Resistance Problem Among the Students of a Medical University

https://doi.org/10.37489/0235-2990-2022-67-1-2-45-52

Abstract

Background. The growth  of antibiotic resistance is an urgent  problem of modern medicine associated with the irrational use of antibacterial drugs. The solution to this problem requires a comprehensive analysis of the situation not only from the patients’ standpoint, but also from that of medical specialists. Aim. To establish the level of awareness about the problem of antibiotic resistance and to study the practice of antibacterial drug use among senior students of a medical university. Material and methods. A one-time sociological study was conducted in the format of an online survey of the 5th–6th year students of the medical and pediatric faculties of the Siberian State Medical  University of the Ministry of Health  of the Russian Federation. Results. An invitation to the survey was sent to 406 5th–6th year students of the pediatric and medical faculties; 334 students voluntarily completed the questionnaire (return  rate — 82.3%). Most students are aware of the problem of antibiotic resistance. 58.8% of the students took drugs as prescribed by a doctor, adhering to the prescribed duration of treatment. The most  commonly used  antibiotics were: amoxicillin/clavulanic acid — 57.6%, amoxicillin — 29%, azithromycin — 19.4%, ciprofloxacin — 13.4%, 3rd  generation cephalosporins — 8.1%. It was found  that 45.4% of students used  antibiotics parenterally, of which  half (50.4%) performed injections at home or in the dormitory. Up to 89.2% of respondents consider it necessary to use medications to restore the intestinal microflora against the back-ground of antibiotic therapy. Conclusions. Despite the high awareness of the problem of antibiotic resistance and adherence to medical recommendations regarding the use of antibiotics, it is necessary to increase the competence in the field of rational antibiotic therapy for both students and practitioners.

About the Authors

M. M. Fedotova
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Marina M. Fedotova — Ph. D. in medicine, Siberian State Medical University of the Ministry of Health of the Russian Federation.

Moskovskiy tract, Tomsk, 634050.

Researcher ID: S-5247-2016

eLIBRARY SPIN: 1488-8189

Scopus Author ID: 55913323000


Competing Interests:

No



V. M. Malchuk
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Victoria N. Malchuk — 2nd year resident of the Pediatrics Department with a course of childhood diseases of the Medical Faculty, Siberian State  Medical University of the  Ministry of Health of the Russian Federation.

Moskovskiy tract, Tomsk, 634050.

eLIBRARY SPIN: 1058-9211


Competing Interests:

No



V. A. Churilin
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Vladimir A. Churilin — 2nd year resident of the  Department of Pediatric Surgical  Diseases, Siberian State Medical University of the Ministry of Health of the Russian Federation.

Moskovskiy tract, Tomsk, 634050.

eLIBRARY SPIN: 5648-9508


Competing Interests:

No



A. A. Zapevalova
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Alevtina A. Zapevalova — 1st   year  resident of the  Pediatrics Department with a course of childhood diseases of the Medical Faculty, Siberian State  Medical University of the  Ministry of Health of the Russian Federation.

Moskovskiy tract, Tomsk, 634050.

eLIBRARY SPIN: 8019-5638


Competing Interests:

No



D. O. Yakovleva
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Darya O. Yakovleva — 1st  year resident of the  Department of Anesthesiology, Resuscitation and  Intensive Care,  Siberian State Medical University of the Ministry of Health of the Russian  Federation.

Moskovskiy tract, Tomsk, 634050.


Competing Interests:

No



D. D. Olenius
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Danil  D. Olenius — 6th year student of the Pediatrics Faculty, Siberian State Medical University of the Ministry of Health of the  Russian Federation.

Moskovskiy tract, Tomsk, 634050.

eLIBRARY SPIN: 1851-3368


Competing Interests:

No



A. M. Kamenshchikova
Maastricht University
Netherlands

Alena  M. Kamenshchikova — researcher at  the  Faculty of Health, Ethics and Society, Maastricht University.

Maastricht.

Scopus Author ID: 57202852086


Competing Interests:

No



S. V. Fedosenko
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Sergey V. Fedosenko — D. Sc. in medicine, Professor, Siberian State Medical University of the Ministry of Health of the Russian  Federation.

Moskovskiy tract, Tomsk, 634050.

Researcher ID: R-3620-2016

eLIBRARY SPIN: 1730-3808.

Scopus Author ID: 55810649200


Competing Interests:

No



O. S. Fedorova
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Olga S. Fedorova  — D. Sc. in medicine, Professor, Siberian State Medical University of the Ministry of Health of the Russian  Federation.

Moskovskiy tract, Tomsk, 634050.

Researcher ID: S-6888-2016

eLIBRARY SPIN: 5285-4593

Scopus Author ID: 18436687900


Competing Interests:

No



References

1. Yakovlev S.V., Briko N.I., Sidorenko S.V., Procenko D.N. Programma SKAT (Strategiya Kontrolya Antimikrobnoj Terapii) pri okazanii stacionarnoj medicinskoj pomoshchi. Rossijskie Klinicheskie Rekomendacii. 2018; 156. (in Russian)

2. Kozlov R.S., Golub A. V. To stop the progress of antimicrobial resistance today means to give a chance of mankind surviving tomorrow. Clin Microbiol Antimicrob Chemother. 2019; 21 (4): 310—315. doi: 10.36488/cmac.2019.4.310-315. (in Russian)

3. Global action plan on antimicrobial resistance WHO. Library Cataloguing-in-Publication Data Global Action Plan on Antimicrobial Resistance. doi: 10.13140/RG.2.2.24460.77448.

4. Jim O’Neill. Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. https://amr-review.org/sites/default/files/AMRReviewPaper—Tacklingacrisisforthehealthandwealthofnations_1.pdf. Published 2014. Accessed September 26, 2020.

5. Naylor N.R., Atun R., Zhu N. et al. Estimating the burden of antimicrobial resistance: a systematic literature review. doi: 10.1186/s13756-018-0336-y.

6. Strategiya preduprezhdeniya rasprostraneniya antimikrobnoj rezistentnosti v Rossijskoj Federacii na period do 2030 goda ot 25 sentyabrya 2017 g. № 2045-r. Dostupno po: http://www.consultant.ru/document/cons_doc_LAW_279129/ Ssylka aktivna na 23.03.2021. (in Russian)

7. Prikaz Minzdrava Rossii ot 11.07.2017 N 403n (red. ot 07.07.2020) «Ob utverzhdenii pravil otpuska lekarstvennyh preparatov dlya medicinskogo primeneniya, v tom chisle immunobiologicheskih lekarstvennyh preparatov, aptechnymi organizaciyami, individual'nymi predprinimatelyami, imeyushchimi licenziyu na farmacevticheskuyu deyatel'nost'» (Zaregistrirovano v Minyuste Rossii 08.09.2017 N 48125). Доступно по: https://www.consultant.ru/cons/cgi/online.cgi?rnd=0A5A5C38C7EBB63336DC2B8A31DC3967&req=doc&base=LAW&n=365105&dst=100014&fld=134&stat=refcode%3D16876%3Bdstident%3D100014%3Bindex%3D0#5g49u6mln3c <https://www.consultant.ru/cons/cgi/online.cgi?rnd=0A5A5C38C7EBB63336DC2B8A31DC3967&req=doc&base=LAW&n=365105&dst=100014&fld=134&stat=refcode%3D16876%3Bdstident%3D100014%3Bindex%3D0>. Ssylka aktivna na 23.03.2021. (in Russian)

8. Ivanchik N.V., Chagaryan A.N., Sukhorukova M.V., Kozlov R.S., Dekhnich A.V., Krechikova O.I. et al. Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017». Klinicheskaya Mikrobiologiya i Antimikrobnaya Khimioterapiya. 2019; 21 (3): 230–237. doi: 10.36488/cmac.2019.3.230-237. (in Russian)

9. Klein E.Y., Van Boeckel T.P., Martinez E.M. et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. 2018; 115 (15): E3463-E3470. doi: 10.1073/pnas.1717295115

10. Van Boeckel T.P., Gandra S., Ashok A. et al. Global antibiotic consumption 2000 to 2010: An analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014; 14 (8): 742–750. doi: 10.1016/S1473-3099(14)70780-7.

11. Antimicrobial consumption — Annual Epidemiological Report for 2018. https://www.ecdc.europa.eu/en/publications-data/surveillance-antimicrobial-consumption-europe-2018#no-link. Accessed January 14, 2021.

12. Yakovlev S.V. New concept of rational use of antibiotics in outpatient practice. Antibiotiki i khimioter. 2019; 64 (3–4): 47–57. doi: 10.24411/0235-2990-2019-10017. (in Russian)

13. Kuzmenkov A.Y., Vinogradova A.G. Antimicrobial resistance monitoring: A review of information resources. Bull Sib Med. 2020; 19 (2): 163–170. doi: 10.20538/1682-0363-2020-2-163-170. (in Russian)

14. Gupta M., Vohra C., Raghav P. Assessment of knowledge, attitudes, and practices about antibiotic resistance among medical students in India. J Fam Med Prim Care. 2019; 8 (9): 2864. doi: 10.4103/jfmpc.jfmpc_504_19.

15. Harakeh S., Almatrafi M., Ungapen H. et al. Perceptions of medical students towards antibiotic prescribing for upper respiratory tract infections in Saudi Arabia. BMJ Open Respir Res. 2015; 2 (1): e000078. doi: 10.1136/bmjresp-2014-000078.

16. Jairoun A., Hassan N., Ali A., Jairoun O., Shahwan M., Hassali M. University students’ knowledge, attitudes, and practice regarding antibiotic use and associated factors: A cross-sectional study in the United Arab Emirates. Int J Gen Med. 2019; 12: 235–246. doi: 10.2147/IJGM.S200641.

17. Fejza A., Kryeziu Z., Kadrija K., Musa M. Pharmacy students’ knowledge and attitudes about antibiotics in Kosovo. Pharm Pract (Granada). 2016; 14 (1): e000078. doi: 10.18549/PharmPract.2016.01.715.

18. Barkus A., Lisauskienė I. Inappropriate habits of antibiotic use among medical specialists and students in Vilnius. Acta medica Litu. 2016; 23 (2). doi: 10.6001/actamedica.v23i2.3330.

19. Dyrbye L.N., West C.P., Satele D., Boone S., Sloan J., Shanafelt T.D. A National study of medical students’ attitudes toward self-prescribing and responsibility to report impaired colleagues. Acad Med. 2015; 90 (4): 485–493. doi: 10.1097/ACM.0000000000000604.

20. Scaioli G., Gualano M.R., Gili R., Masucci S., Bert F., Siliquini R. Antibiotic Use: A cross-sectional survey assessing the knowledge, attitudes and practices amongst students of a school of medicine in Italy. PLoS One. 2015; 10 (4). doi: 10.1371/journal.pone.0122476.

21. Dyar O.J., Hills H., Seitz L.T., Perry A., Ashiru-Oredope D. Assessing the knowledge, attitudes and behaviors of human and animal health students towards antibiotic use and resistance: a pilot cross-sectional study in the UK. Antibiotics. 2018; 7 (1). doi: 10.3390/antibiotics7010010.

22. Hu Y., Wang X., Tucker J.D. et al. Knowledge, attitude, and practice with respect to antibiotic use among Chinese medical students: A multicentre cross-sectional study. Int J Environ Res Public Health. 2018; 15 (6). doi: 10.3390/ijerph15061165.

23. Strategiya i taktika ratsionalnogo primeneniya antimikrobnykh sredstv v ambulatornoy praktike: Evraziyskie klinicheskie rekomendatsii. Pod red. S.V.YAkovleva, S.V.Sidorenko, V.V.Rafalskogo, T.V.Spichak. M.:Izdatelstvo «Pre100 Print», 2016; 144. (dostupno na sayte: www.antimicrob.net). (in Russian)

24. Shankar P.R., Partha P., Shenoy N. Self-medication and non-doctor prescription practices in Pokhara valley, Western Nepal: A questionnaire-based study. BMC Fam Pract. 2002; 3 (1): 1–7. doi: 10.1186/1471-2296-3-17.

25. Harper N.J.N., Cook T.M., Garcez T. et al. Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6). Br J Anaesth. 2018; 121 (1): 159–171. doi: 10.1016/j.bja.2018.04.014.

26. Blumenthal K.G., Peter J.G., Trubiano J.A., Phillips E.J. Antibiotic allergy. Lancet. 2019; 393 (10167): 183–198. doi:10.1016/S0140-6736(18)32218-9.

27. Nepal A., Hendrie D., Robinson S., Selvey L.A. Knowledge, attitudes and practices relating to antibiotic use among community members of the Rupandehi District in Nepal. BMC Public Health. 2019; 19 (1): 1558. doi: 10.1186/s12889-019-7924-5.

28. Aljayyousi G.F., Abdel-Rahman M.E., El-Heneidy A., Kurdi R., Faisal E. Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members. PLoS One. 2019; 14 (11). doi: 10.1371/journal.pone.0225499.

29. Sakeena M.H.F., Bennett A.A., Jamshed S. et al. Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities. BMC Infect Dis. 2018; 18 (1): 209. doi: 10.1186/s12879-018-3107-8.


Review

For citations:


Fedotova M.M., Malchuk V.M., Churilin V.A., Zapevalova A.A., Yakovleva D.O., Olenius D.D., Kamenshchikova A.M., Fedosenko S.V., Fedorova O.S. The Use of Antibacterial Drugs and Awareness About the Antibiotic Resistance Problem Among the Students of a Medical University. Antibiot Khimioter = Antibiotics and Chemotherapy. 2022;67(1-2):45-52. (In Russ.) https://doi.org/10.37489/0235-2990-2022-67-1-2-45-52

Views: 7078


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0235-2990 (Print)