Pathogenetic Therapy in Patients with Recurrent Herpetic Infection

When treating patients with recurrent herpesvirus infection, it is necessary to use combination therapy, which involves the use of both chemotherapy and immunotropic drugs. Simultaneous use of drugs with different mechanisms of action allows to achieve greater efficiency than the use of monotherapy. The effectiveness of Cycloferon, an interferon inducer, which has an anti-inflammatory and immunomodulatory effect in combination therapy in patients with labial herpes, has been established. An accelerated elevation of rashes was observed against the background of the use of Cycloferon in combination therapy with acyclic nucleosides (Acyclovir); the severity of general intoxication syndrome, subjective symptoms (pain, itching, burning), and signs of inflammation (edema, hyperemia) decreased by half compared with the control group. Also, an increase in the duration of remission by 2–2.5 times was observed in patients taking Cycloferon. High efficiency, good tolerance by patients, as well as the possibility of using it with the main antiviral chemotherapy drugs indicate the advisability of including Cycloferon in the combination therapy in patients with recurrent herpes infection.

1. Isakov D.V., Isakov V.A. Novye aspekty patogeneza prostogo gerpesa. Vestnik Gematologii. 2016; 12 (4): 13–18. (in Russian)

2. Isakov V.A., Arkhipova E.I., Isakov D.V. Gerpes virusnye infektsii cheloveka. 2-e izd. pererab. dop.: rukovodstvo dlya vrachej. / Pod red. V.A. Isakova. SPb.: Spets Lit, 2013; 670. ISBN 978-5-299-00454-0. (in Russian)

3. Kambachokova Z.A. Pokazateli kletochnogo i gumoral'nogo immuniteta u bol'nykh genital'nym gerpesom. Vestnik Bashkortostana. 2012; 3: 46–49. (in Russian)

4. Vikulov G.Kh. Immunologicheskie aspekty gerpes-virusnykh infektsij. Klinicheskaya dermatologiya i venerologiya. 2015; 14 (5): 104–116. (in Russian)

5. Jiang X., Chentoufi A.A., Hsiang C. et al. The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme Binduced apoptosis and CD8 T-cell killing. J Virol. 2011; 85 (5): 2325–2332. doi:10.1128/JVI.01791-10. Epub 2010 Dec 22.

6. Nagoev B.S., Kamachokova Z.A. Tsitokinovyj status u bol'nykh gerpesvirusnymi infektsiyami. Infektsionnye Bolezni. 2011; 9 (1): 19–22. (in Russian)

7. Veretennikova M.A. Sovremennaya farmakoterapiya gerpesa s ispol'zovaniem razlichnykh lekarstvennykh form. Fundamental'nye issledovaniya. 2014; 7–8: 1630–1634. (in Russian)

8. Nagoev B.S., Kambachokova Z.A. Tsitokinovyj status bol'nykh s gerpesvirusnymi infektsiyami. Infektsionnye bolezni. 2011; 11 (1): 19–23. (in Russian)

9. Mardanly S.G., Arsen'eva V.A., Mardanly S.S., Rotanov S.V. Rasprostranennost' virusov gerpesa cheloveka sredi kontingentov razlichnogo vozrasta. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii. 2019; 2: 50–55. (in Russian)

10. Pron'kina N.S., Bulygin G.V., Kamzalakova N.I., Tikhonova Jyu.S. Kharakteristika parametrov immunnogo statusa u bol'nykh khronicheskoj gerpeticheskoj infektsiej s formirovaniem sindroma khronicheskoj ustalosti i immunnoj disfunktsii. Fundamental'nye issledovaniya. 2013; 5 (1): 124–128. (in Russian)

11. Alimbarova L.M. Primenenie Tsikloferona pri lechenii gerpes virusnoj infektsii. Antibiotiki i khimioter. 2014; 59 (3–4): 22–29.[ Alimbarova L.M. Primenenie Tsikloferona pri lechenii gerpes virusnoj infektsii. Antibiotiki i Khimioter. 2014; 59 (3-4): 22–29. (in Russian)

12. Bazhanova E.D. Tsikloferon: mekhanizm dejstviya, funktsii i primenenie. Eksperimental'naya Klinicheskaya Farmakologiya. 2012; 75 (7): 40–44. (in Russian)

13. Povalyaeva D.A., Egorov V.V., Smolyakova G.P., Danilova L.P. Klinicheskaya otsenka primeneniya tsikloferona v kompleksnom lechenii patsientov s ostrym gerpesvirusnym opticheskim nevritom. Vestnik VolgGMU. 2018; 4 (68): 28–32. (in Russian)

14. Kambachokova Z.A., Khamurzova M.A., Aramisova R.M. Immunopatogeneticheskie narusheniya u bol'nykh gerpesvirusnymi infektsiyami. Antibiotiki i Khimioter. 2020; 65 (9–10): 28–31. (in Russian)

15. Kambachokova Z.A., Aramisova R.M., Shogenova M.S. et al. Anti-inflammatory cytokinin is in blood serum of patients with recurrent genital herpes. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2018; 9 (6): 223–227.