By flow cytometry it was demonstrated that lipopolysaccharide and exopolysaccharide of marine proteobacteria Pseudoalteromonas nigrifaciens alter the expression of adhesion molecules on human neutrophils and monocytes, reducing the expression level of molecules CD62L and increasing the expression of CD11b, CD11c and CD54.

Prophylactic efficacy of Triazavirin against experimental Forest-Spring encephalitis was studied on albino mice vs. the active drug Ribavirin®. A significant increase of the animal lifespan in the test groups (from 4 to 5 days) and a statistically (р<0.05) valid decrease of the virus accumulation level in the target organ (the brain) were observed.

The effcacy of Remaxol was studied in the treatment of patients with acute biliary pancreatitis under clinical and laboratory conditions by the recommended indices, as well as by the markers of endogenous intoxication, the intensity of lipid peroxidation, activity of some enzymes and indicators of hypoxia. The use of Remaxol in the treatment of acute biliary pancreatitis was highly resultant in correction (prevention of progression) of the functional hepatic failure and homeostatic disorders as a whole. It was demonstrated that the hepatoprotective effect of the drug was based on its ability to reduce oxidative stress, to inhibit excessive phospholipase activity and to alleviate the signs of general hypoxia.

The up-to-date literature and original data on the epidemiology, diagnosis and treatment of toxoplasmosis are presented. Particular attention is paid to the parasite infection during pregnancy. Spiramycin is the drug of choice for acute toxoplasmosis in pregnant women.

The efficacy of merbid abesity therapy of present remains rather low. Bariatric surgery is one of the most efficient methods for the treatment. Safety, efficacy and favourable results of the surgery are provided only after thorough examination of the patients.

Streptomycetes or mycelial microorganisms are able to form biofilms under the natural, industrial and clinical conditions. The controlled use of biofilms in various industrial processes is much more efficient vs. the cultivation of plankton suspended cells. Optimization of biotechnological processes with the use of streptomycete biofilms is advisable in production of lactic acid and detoxication of the liquor in pyrolysis of plant biomass. Streptomycete biofilms are used in water purification systems. It is recommended to use biofilms for detoxication of wastes and bioremediation of soils contaminated with hard metals. The use of biofilms of streptomycetes producing biologically active substances is of special interest. High yields of antibiotics and actinomycin D in particular was observed with cultivation of antibioc-producing streptomycetes as biofilms in bioreactors of unique design.

The literature data on possible optimization of the arterial hypertension management with organoprotective antihypertensive agents are reviewed. Olmesartan is one of the most thoroughly investigated agents blocking the receptors to angiotensin-II that shows antihypertensive effect and has cardiovaso- and nephroprotective as well as pleotropic properties. The use of Olmesartan is based on the principles of proof medicine.