Current Concepts of the Peptide Antibiotic Gramicidin S Biosynthesis
https://doi.org/10.37489/0235-2990-2025-70-5-6-64-71
EDN: KPGFFW
Abstract
Gramicidin S is a cyclic decapeptide antibiotic produced by the soil bacterium Aneurinibacillus migulanus (formerly Bacillus brevis, Brevibacillus brevis), one of the first antibiotics ever discovered. In recent years, a revival of research interest was observed towards gramicidin S due to its unique properties: it does not cause the development of antibiotic resistance and has high efficacy against biofilms. This review examines current understanding of the structure, biological role, and antimicrobial mechanisms of gramicidin S. It also explores the biosynthetic pathways of gramicidin S, as well as the influence of cultivation parameters and nutrient medium components on its biosynthesis.
About the Authors
E. R. Mitina
MIREA — Russian technological university
Russian Federation
Competing Interests:
Russian Federation
Ekaterina R. Mitina, Assistant
Institute of Fine Chemical Technologies; Department of Biotechnology and Industrial Pharmacy
Moscow
Competing Interests:
The authors declare that there is no conflict of interest
A. B. Pshenichnikova
MIREA — Russian technological university
Russian Federation
Competing Interests:
Russian Federation
Anna B. Pshenichnikova, Ph. D. in Chemistry, Associate Professor
Institute of Fine Chemical Technologies; Department of Biotechnology and Industrial Pharmacy
Moscow
Competing Interests:
The authors declare that there is no conflict of interest
O. V. Efremenkova
Gause Institute of New Antibiotics
Russian Federation
Competing Interests:
Russian Federation
Olga V. Efremenkova, Ph. D. in Biology, Head of the Sector
Resistance-Overcoming Natural Compounds Search Sector
Moscow
Competing Interests:
The authors declare that there is no conflict of interest
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Review
For citations:
Mitina ER, Pshenichnikova AB, Efremenkova OV. Current Concepts of the Peptide Antibiotic Gramicidin S Biosynthesis. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2025;70(5-6):64-71. (In Russ.) https://doi.org/10.37489/0235-2990-2025-70-5-6-64-71. EDN: KPGFFW
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