Blood Culture-Negative Endocarditis
https://doi.org/10.37489/0235-2990-2025-70-5-6-72-80
EDN: XSDNPT
Abstract
Blood culture–negative endocarditis (BCNE) is an important clinical problem, since the identification of the pathogen and its sensitivity to anti-infective drugs is crucial to ensure optimal treatment of this disease. The most common causes of BCNE are the administration of antibiotics before blood culture for examination or infection with microorganisms that require special techniques and special equipment to identify them. Recognizing the extreme urgency of this problem, the American Heart Association issued a special statement, with a number of key achievements in the field of molecular diagnostics introduced into practice in recent years, as well as a variety of imaging techniques that help identify cardiac and extracardiac lesions as the leading source of motivation. This article comments on the main provisions of this document.
Keywords
Blood culture-negative endocarditis,
epidemiological factors,
molecular biological diagnostics,
imaging methods,
antibacterial therapy
Supporting agencies: The article was prepared as part of the research work of the Federal State Budgetary Scientific Institution “V. A. Nasonova Research Institute of Rheumatology”, No. of the state task of the Republic of Kazakhstan 125020301268-4. The study did not have sponsorship
About the Authors
B. S. Belov
V. A. Nasonova Research Institute of Rheumatology
Russian Federation
Competing Interests:
Russian Federation
Boris S. Belov, D.Sc. in Medicine, Head of the Laboratory
Laboratory of Comorbid Infections and Vaccine Prevention
Moscow
Researcher ID: ABD-2219-2020; Scopus Author ID: 7004592537
Competing Interests:
There is no conflict of interest. The authors are fully responsible for submitting the final version of the manuscript for publication. All authors participated in the development of the article's concept and the writing of the manuscript. The final version of the manuscript was approved by all authors
G. M. Tarasova
V. A. Nasonova Research Institute of Rheumatology
Russian Federation
Competing Interests:
Russian Federation
Galina M. Tarasova, Ph.D. in Medicine, Senior Researcher
Laboratory of Thromboinflammation
Moscow
Researcher ID: AAF-3477-2021; Scopus Author ID: 7005497817
Competing Interests:
There is no conflict of interest. The authors are fully responsible for submitting the final version of the manuscript for publication. All authors participated in the development of the article's concept and the writing of the manuscript. The final version of the manuscript was approved by all authors
N. V. Muravyeva
V. A. Nasonova Research Institute of Rheumatology
Russian Federation
Competing Interests:
Russian Federation
Natalia V. Muravyeva, Ph.D. in Medicine, Senior Researcher
Laboratory of Comorbid Infections and Vaccine Prevention
Moscow
ResearcherID: AAF-4853-2021; Scopus Author ID: 57210263706
Competing Interests:
There is no conflict of interest. The authors are fully responsible for submitting the final version of the manuscript for publication. All authors participated in the development of the article's concept and the writing of the manuscript. The final version of the manuscript was approved by all authors
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For citations:
Belov BS, Tarasova GM, Muravyeva NV. Blood Culture-Negative Endocarditis. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2025;70(5-6):72-80. (In Russ.) https://doi.org/10.37489/0235-2990-2025-70-5-6-72-80. EDN: XSDNPT
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