Сhronic stress as a risk factor for dyslipidemia, cardiovascular disease, and arterial hypertension: a systematic review and meta-analysis of alternative interventions
https://doi.org/10.37489/0235-2990-2025-71-1-2-77-81
EDN: JZRTRY
Abstract
Chronic psychosocial stress, dietary patterns, and physical activity levels are important modifiable factors of cardiovascular risk. Their influence is mediated through behavioral, neuroendocrine, metabolic, and psychophysiological mechanisms. The aim of this review was to systematize data on the relationship between stress, dietary patterns, physical activity, and cardiovascular risk based on a predefined literature. The analysis was based on 15 publications, including meta-analyses, systematic reviews, clinical trials, and conceptual papers on stress, hypertension, diet, cardiorespiratory fitness, mindfulness, as well as relaxation interventions. Chronic stress has been shown to be associated with a higher risk of hypertension, while social support, mindfulness-based interventions, the Mediterranean diet, soluble fiber, omega-3 fatty acids, and physical activity have been associated with a more favorable cardiometabolic profile. The integration of psychological and nutritional interventions, along with physical activity, may be considered a promising strategy for the prevention of cardiovascular disease.
About the Authors
R. Kh. MakhievRussian Federation
Rasul Kh. Makhiev — first-year resident physician, Medical Academy
Nalchik
Z. A. Kambachokova
Russian Federation
Zareta A. Kambachokova — D. Sc. in Medicine, Professor, Department of Hospital Therapy, Medical Academy
Nalchik
M. Zh. Attaeva
Russian Federation
Madina Zh. Attaeva — Ph. D. in Medicine, Associate Professor, Department of Hospital Therapy, Medical Academy
Nalchik
R. Kh. Akhmatov
Russian Federation
Ramazan Kh. Akhmatov — 6th-year student in the General Medicine program, Medical Academy
Nalchik
S. V. Makhadzhiev
Russian Federation
Suleiman V. Makhadzhiev — 6th-year student in the General Medicine program, Medical Academy
Nalchik
L. A. Kazharova
Russian Federation
Lyana A. Kazharova — 6th-year student in the General Medicine program, Medical Academy
Nalchik
E. S. Zhereshtieva
Russian Federation
Elina S. Zhereshtieva — 6th-year student in the General Medicine program, Medical Academy
Nalchik
A. M. Khazhnagoeva
Russian Federation
Albina M. Khazhnagoeva — 6th-year student in the General Medicine program, Medical Academy
Nalchik
D. I. Saidulkhanov
Russian Federation
Deni I. Saidulkhanov — 6th-year student in the General Medicine program, Medical Academy
Nalchik
B. R. Tembulatova
Russian Federation
Birlant R. Tembulatova — 6th-year student in the General Medicine program, Medical Academy
Nalchik
M. M. Shagiriev
Russian Federation
Magomed M. Shagiriev — 6th-year student in the General Medicine program, Medical Academy
Nalchik
T. A. Istamulova
Russian Federation
Tasmila A. Istamulova — 6th-year student in the General Medicine program, Medical Academy
Nalchik
A-Kh. V. Tsitsiev
Russian Federation
Abdul-Khamid V. Tsitsiev — 6th-year student in the General Medicine program, Medical Academy
Nalchik
References
1. Liu M-Y, Li N, Li WA, Khan H. Association between psychosocial stress and hypertension: a systematic review and meta-analysis. Neurol Res. 2017; 39 (6): 573–580. doi: 10.1080/01616412.2017.1317904.
2. Kivimäki M, Steptoe A. Effects of stress on the development and progression of cardiovascular disease. Nat Rev Cardiol. 2018; 15 (4): 215–229. doi: 10.1038/nrcardio.2017.189
3. Cohen S, Wills TA. Stress, social support, and the buffering hypothesis. Psychol Bull. 1985; 98 (2): 310–357.
4. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. 1999; 69 (1): 30–42. doi: 10.1093/ajcn/69.1.30.
5. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007; 369 (9567): 1090–1098. doi: 10.1016/S0140-6736(07)60527-3.
6. Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA. 2009; 301 (19): 2024–2035. doi: 10.1001/jama.2009.681.
7. Grossman P, Niemann L, Schmidt S, Walach H. Mindfulness-based stress reduction and health benefits: a meta-analysis. J Psychosom Res. 2004; 57 (1): 35–43. doi: 10.1016/S0022-3999(03)00573-7.
8. Hofmann SG, Sawyer AT, Witt AA, Oh D. The effect of mindfulnessbased therapy on anxiety and depression: a meta-analytic review. J Consult Clin Psychol. 2010; 78 (2): 169–183. doi: 10.1037/a0018555.
9. Manzoni GM, Pagnini F, Castelnuovo G, Molinari E. Relaxation training for anxiety: A ten-years systematic review with meta-analysis. BMC Psychiatry. 2008; 8: 41. doi: 10.1186/1471-244X-8-41.
10. Tudor-Locke C, Bassett DR. How many steps/day are enough? Preliminary pedometer indices for public health. Sports Med. 2004; 34 (1): 1–8. doi: 10.2165/00007256-200434010-00001.
11. Estruch R, Ros E, Salas-Salvadó J, Covas M-I, Corella D, Arós F, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013; 368 (14): 1279–1290. doi: 10.1056/NEJMoa1200303.
12. Lassale C, Batty GD, Baghdadli A, Jacka F, Sánchez-Villegas A, Kivimäki M, Akbaraly T. Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies. Mol Psychiatry. 2019; 24 (7): 965–986. doi: 10.1038/s41380-018-0237-8.
13. Foster JA, McVey Neufeld K-A. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 2013; 36 (5): 305–312. doi: 10.1016/j.tins.2013.01.005.
14. Kraemer WJ, Adams K, Cafarelli E, Dudley GA, Dooly C, Feigenbaum MS. American college of sports medicine. american college of sports medicine position stand: progression models in resistance training for healthy adults. Med Sci Sports Exerc. 2002; 34 (2): 364–380. doi: 10.1097/00005768-200202000-00027.
15. Volpe SL. Magnesium and the athlete. Curr Sports Med Rep. 2015; 14 (4): 279–283. doi: 10.3945/an.112.003523.
Review
For citations:
Makhiev RK, Kambachokova ZA, Attaeva MZ, Akhmatov RK, Makhadzhiev SV, Kazharova LA, Zhereshtieva ES, Khazhnagoeva AM, Saidulkhanov DI, Tembulatova BR, Shagiriev MM, Istamulova TA, Tsitsiev AV. Сhronic stress as a risk factor for dyslipidemia, cardiovascular disease, and arterial hypertension: a systematic review and meta-analysis of alternative interventions. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2026;71(1-2):77-81. (In Russ.) https://doi.org/10.37489/0235-2990-2025-71-1-2-77-81. EDN: JZRTRY
JATS XML
















































