Резистентность к противогрибковым средствам: роль кальцинейрина и протеинкиназ

1. Jamal Stie J., Fox D. Calcineurin Regulation in Fungi and Beyond. Eukaryotic Cell 2008; 7: 2: 177-186.

2. Karababa M., Valentino E., Pardini G., Coste A.T. et al. CRZ1, a target of the calcineurin pathway in Candida albicans. Mol Microbiol 2006; 59: 1429-1451.

3. Onyewu C., Wormley F.L. Jr., Perfect J.R., Heitman J. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun 2004; 72: 7330-7333.

4. Kraus P.R., Fox D.S., Cox G.M., Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol 2003; 48: 1377-1387.

5. Cowen L.E., Lindquist S. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 2005; 309: 2185-2189.

6. Cowen L.E., Carpenter A.E., Matangkasombut O., Fink G.R. et al. Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell 2006; 5: 2184-2188.

7. Cowen L.E., Steinbach W.J. Stress, drugs and evolution: the role of cellular signaling in fungal drug resistance. Eukaryotic Cell 2008; 7: 5: 747-764.

8. Jain P., Akula I., Edlind T. Cyclic AMP signaling pathway modulates susceptibility of Candida species and Saccharomyces cerevisiae to antifungal azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother 2003; 47: 3195-3201.

9. Wiederhold N.P., Kontoyiannis D.P., Prince R.A., Lewis R.E. Attenuation of the activity of caspofungin at high concentrations against Candida albicans: possible role of cell wall integrity and calcineurin pathways. Ibid 2005; 49: 5146-5148.

10. Chauhan N., Kruppa M., Calderone R. The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. Ibid; 2007; 51: 3747-3751.

11. Steinbach W.J., Schell W.A., Blankenship J.R., Onyewu C. et al. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Ibid; 2004; 48: 1664-1669.

12. Steinbach W.J., Cramer R.A. Jr., Perfect B.Z., Henn C. et al. Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Ibid; 2007; 51: 2979-2981.

13. Del Poeta M., Cruz M.C., Cardenas M.E., Perfect J.R. et al. Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumo-candin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Ibid; 2000; 44: 739-746.

14. Kraus P.R., Fox D.S., Cox G.M., Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol 2003; 48: 1377-1387.

15. Kojima K., Bahn Y.S., Heitman J. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 2006; 152: 591-604.