In vitro Efficacy of Ingavirin Against the Mexican Pandemic Subtype H1N1 of Influenza A Virus, Strains A/California/04/2009 and A/California/07/2009
Abstract
Ingavirin® was shown to be efficient in inhibition of the influenza virus strains A/California/04/2009 and A/California/07/2009 (H1N1) in the MDCK cell culture. The coefficient of the cytopathic activity inhibition amounted to 50 and 60%, and the inhibition coefficients of the specific hemagglutinin formation were 50 and 50%, and 79,1 and 75% before and after the enrichment in chick embryos respectively.
About the Authors
S. YA. Loginova
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Россия
Россия
S. V. Borisevich
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Россия
Россия
M. V. Lykov
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Россия
Россия
E. V. Vedenina
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Россия
Россия
G. V. Borisevich
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Россия
Россия
V. P. Bondarev
Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev Posad
Россия
Россия
V. E. Nebolsin
Valenta Farmacevtica, Moscow
Россия
Россия
A. G. Chuchalin
Research Institute of Pulmonology, Federal Medico-Biological Agency of the Russian Federation, Moscow
Россия
Россия
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Review
For citations:
Loginova SY, Borisevich SV, Lykov MV, Vedenina EV, Borisevich GV, Bondarev VP, Nebolsin VE, Chuchalin AG. In vitro Efficacy of Ingavirin Against the Mexican Pandemic Subtype H1N1 of Influenza A Virus, Strains A/California/04/2009 and A/California/07/2009. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2009;54(3-4):15-17. (In Russ.)
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