Infective Endocarditis of Staphylococcal Etiology: Clinical Process and Antibacterial Therapy
Abstract
Characteristics of the clinical process of staphylococcal endocarditis in 115 inpatients and the adequacy of various regimens for their antibiotic therapy within a period of 10 years were analysed. Four clinical criteria for prognosis of staphylococcal endocarditis were determined: intravenous narcomania, splenomegalia, leukocytosis and hemorrhagic skin eruption. The analysis of the Russian and foreign findings showed that the use of betalactams (oxacillin, the 1st and 3rd generation cephalosporins) and lincomycin provided the adequate therapy resulting in eradication of the pathogen in case of oxacillin resistant staphylococci, whereas the use of ciprofloxacin and vancomycin was inexpedient. In case of MRSA it was recommended to use vancomycin and in case of endocarditis due to S.aureus with intermediate resistance to vancomycin (VISA, MIC > 0.5 mcg/ml) the use of line-zolid was recommended.
About the Authors
S. V. Yakovlev
I. M. Sechenov Moscow Medical Academy; Municipal Clinical Hospital No.7, Moscow
Russian Federation
Russian Federation
D. V. Shcheka
I. M. Sechenov Moscow Medical Academy; Municipal Clinical Hospital No.7, Moscow
Russian Federation
Russian Federation
M. P. Suvorova
I. M. Sechenov Moscow Medical Academy; Municipal Clinical Hospital No.7, Moscow
Russian Federation
Russian Federation
E. V. Sergeeva
I. M. Sechenov Moscow Medical Academy; Municipal Clinical Hospital No.7, Moscow
Russian Federation
Russian Federation
N. A. Cherkasova
I. M. Sechenov Moscow Medical Academy; Municipal Clinical Hospital No.7, Moscow
Russian Federation
Russian Federation
References
1. Cabell C. H., Andeson D. V., Buell H. E. et al. The changing face of endocarditis in the 1990s. 40th ICAAC (9/17/2000 through 9/20/2000).
2. Miro J. M., Anguera I., Cabell C. H. et al. Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis. Clin Infect Dis 2005; 41: 507-514.
3. Николаевский E. H., Хубулава Г. Г., Удальцов Б. Б. Инфекционный эндокардит (современное состояние проблемы): Монография. Самара: 2006. 198.
4. Drinkovic D., Morris A. J., Pottumarthy S. et al. Bacteriological outcome of combination versus single-agent treatment for staphylococcal endocarditis. J Antimicrob Chemother 2003; 52: 820-825.
5. Lee S. H., Chung M. H., Lee J. S. et al. A case of Staphylococcus aureus endocarditis after ear piercing in a patient with normal cardiac valve and a questionnaire survey on adverse events of body piercing in college students of Korea. Scand J Infect Dis 2006; 38: 2: 130-132.
6. Pistella E., Campanile F., Bongiorno D. et al. Successful treatment of disseminated endocarditis unresponsive to vancomycin therapy with linezolid. Scand J Infect Dis 2004; 36 (3): 222-225.
7. Белов Б. С. Инфекционный эндокардит II. Особенности течения, критерии диагноза, дифференциальная диагностика. Инфекц антимикроб тер 2004; 4: 120-123.
8. Mandell G. L., Bennett J. E., Dolin R. Principles and practice of infectious diseases. 2000; 857-892.
9. Petti C. A., Fowler V. G. Jr. Staphylococcus aureus bacteriemia and endocarditis. Infect Dis Clin North Am 2002; 16: 413.
10. Le T., Bayer A. S. Combination antibiotic therapy for infective endocarditis. Clin Infect Dis 2003; 36: 615-621.
11. Тюрин В. П. Острый инфекционный эндокардит: тактика ведения и лечения. Сердце 2003; 5: 226-230.
12. Белобородов В. Б. Инфекционный эндокардит. Стратегия выбора антибактериальной терапии. Сердце 2003; 5: 242-247.
13. Белов Б. С. Инфекционный эндокардит III. Лечение и профилактика. Инфекц антимикроб тер 2004; 5: 149-154.
14. Fortun J., Navas E., Martinez-Beltran J. et al. Short-course therapy for right-side endocarditis due to Staphylococcus aureus in drug abusers: cloxacillin versus glycopeptides in combination with gentamicin. Clin Infect Dis 2001; 33: 120-125.
15. Jones R. N. Key considerations in the treatment of complicated staphylococcal infections. Clin Microbiol Infect 2008; 14: Suppl 2: 3-9.
16. Sakoulas G., Moise-Broder P., Schentag G. et al. Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteriemia. J Clin Microbiol 2004; 42: 6: 2398-2402.
17. Soriano A., Marco F., Martinez J. et al. Influence of vancomycin minimum inhibitory concentrations on the treatment of methicillin-resistant Staphylococcus aureus bacteriemia. Clin Infect Dis 2008; 46: 193-200.
18. Neoh H., Hori S., Komatsu M. et al. Impact of reduced vancomycin susceptibility on the therapeutic outcome of MRSA bloodstream infections. Ann Clin Microbiol Antimicrob 2007; 6: 13: 1-6.
19. DiNubile M. J. Short-course antibiotic therapy for right-sided endocarditis caused by Staphylococcus aureus in injection drug users. Clin Infect Dis 2001; 33: 120-125.
20. Tsagonis T., Skiadas I., Koutoukas P. et al. Efficacy and pharmacodynamics of linezolid, alone and in combination with rifampicin, in an experimental model of methicillin-resistant Staphylococcus aureus endocarditis.
21. Jacqueline C., Batard E., Perez I. et al. In vivo efficacy of continious infusion versus intermittent dosing of linezolid compared to vancomycin in a methicillin-resistant Staphylococcus aureus rabbit endocarditis model. Antimicrob Agents Chemother 2002; 46: 3706-3711.
22. Munoz P., Rodriguez-Creixems M., Moreno M. et al. Linezolid therapy for infectious endocarditis. Clin Microbiol Infect 2007; 13: 211-215.
23. Falagas M. E., Manta K. G., Ntziora F. et al. Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence. J Antimicrob Chemother 2006; 58: 273-280.
24. Белобородова H. В., Кузнецова С. Т., Вострикова Т. Ю. и др. Первый опыт клинического применения нового антибиотика линезолида в кардиохирургии. Антибиотики и химиотер 2003; 48: 8: 11-16.
25. Белобородова Н. В., Седракян А. Р. Место линезолида в лечении инфекционного эндокардита. Инфекции и антимикробная терапия 2008; Альманах «Инфекции в стационаре», 6-10.
26. Falagas M. E., Matthaiou D. K., Bliziotis I. The role of aminoglycosides in combination with beta-lactam for the treatment of bacterial endocarditis: a meta-analysis of comparative trials. J Antimicrob Chemother 2006; 57: 639-647.
Review
For citations:
Yakovlev S.V., Shcheka D.V., Suvorova M.P., Sergeeva E.V., Cherkasova N.A. Infective Endocarditis of Staphylococcal Etiology: Clinical Process and Antibacterial Therapy. Antibiot Khimioter = Antibiotics and Chemotherapy. 2009;54(5-6):59-64. (In Russ.)
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