Устойчивость микроорганизмов к антибиотикам: резистома, её объём, разнообразие и развитие
Аннотация
Рассмотрены существующие представления о резистоме как совокупности всех генов резистентности к антибиотикам в геномах всех микроорганизмов - патогенных и непатогенных, живущих в природных условиях. Приведены сведения, касающиеся происхождения, эволюции и распространения генов устойчивости к антибиотикам, а также возможных подходов к контролю распространения устойчивости.
Об авторах
К. А. Виноградова
Московский государственный университет им. М.В. Ломоносова
Россия
Россия
В. Г. Булгакова
Московский государственный университет им. М.В. Ломоносова
Россия
Россия
А. Н. Полин
Московский государственный университет им. М.В. Ломоносова
Россия
Россия
П. А. Кожевин
Московский государственный университет им. М.В. Ломоносова
Россия
Россия
Список литературы
1. D'Costa V.M., McGrann K.M., Hughes D.W., Wright G.D. Sampling the antibiotic resistome. Science 2006; 311: 5759: 374-377.
2. Allen H.K., Moe L.A., Rodbamrer J. et al. Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soil. ISML J 2009; 3: 2: 243-251.
3. Canton R. Antibiotic resistance genes from the environment: a perspective through newly identified antibiotic resistance mechanisms in the clinical setting. Clin Microbiol Infect 2009; 15: Suppl. 1: 20-25.
4. Martinez J.L. The role of natural environments in the evolution of resistance traits in pathogenic bacteria. Proc Biol Sci 2009; 276: 1667: 2521-2530.
5. Wright G.D. Antibiotic resistance in the environment: a link to the clinic? Curr Opin Microbiol 2010; 13: 5: 589-594.
6. Aminov R.I. Horizontal gene exchange in environmental microbiota. Front microbiol 2011; 2: 158.
7. Wright G.D. The antibiotic resistome: the nexus of chemical and genetic diversity. Nat Rev Microbiol 2007; 5: 3: 175-186.
8. D'Costa V.M., Griffiths E., Wright G.D. Expanding the soil antibiotic resistome: exploring environmental diversity. Curr Opin Microbiol 2007; 10: 5: 481-489.
9. Riesenfeld C.S., Goodman R.M., Handelsman J. Uncultured soil bacteria are a reservoir of new antibiotic resistance genes. Environ Microbiol 2004; 6: 9: 981-989.
10. Aminov R.I. and Mackie R.I. Evolution and ecology of antibiotic resistance genes. FEMS Microbiol Lett 2007; 271: 2: 147-161.
11. Mori T., Mizuta S., Suenaga H., Miyazaki K. Metagenomic screeniung for bleomycin resistance genes. Appl Environ Microbiol 2008; 74: 21: 6803-6805.
12. Monier J.-M., Demanèche S., Delmont T.O. et al. Metagenomic exploration of antibiotic resistance in soil. Curr Opin Microbiol 2011; 4: 3: 236-243.
13. Biyela P.T., Lin J., Bezuidenhout C.C. The role of aquatic ecosystems as reservoir of antibiotic resistant bacteria and antibiotic resistance genes. Water Sci Technol 2004; 50:1: 45-50.
14. Song J.S., Jeon J.H., Lee et al. Molecular characterization of TEM-type beta-lactamases identified in cold-seep sediments of Edison Seamount (south of Lihir Island, Papua NewGuinea). J Microbiol 2005; 43: 2: 172-178.
15. Baquero F., Martinez J.L., Canton R. Antibiotic and antibiotic resistance in water environments. Curr Opin Biotechnol 2008, 19: 3: 260-265.
16. Demaneche S., Sanguin H., Pote J. et al. Antibiotic-resistant soil bacteria in transgenic plant fields. Proc Natl Acad Sci USA 2008; 105: 10: 3957-3962.
17. Dib J.R., Weiss A., Neumann A. et al. Isolation of bacteria from remote high altitude Andean lake able to grow in presence of antibiotics. Recent Patents on Anti-Infective Drug Discovery, 2009; 4: 1: 66-76.
18. Pontes D.S., Pinheiro F.A., Lima-Bittencourt C.I. et al. Multiple antimicrobial resistance of gram-negative bacteria from natural oligotrophic lakes under distinct anthropogenic influence in a tropical region. Microb Ecol 2009; 58: 4: 762-772.
19. Wardwell L.H., Jude B.A., Moody J.P. et al. Co-selection of mercury and antibiotic resistance in sphagnumcore samples dating back 2000 years. Geomicrobiology J 2009; 26: 4: 238-247.
20. Bowden M. Science vs. Evolution. 1991 (Bromley, Kent, England: Soverein Publications).
21. Lima-Bittrencourt C.I., Cursino L., Gonçalves-Dotnelas H. Multiple antimicrobial resistance in Enterobacteriaceae isolates from pristine freshwater. Genet Mol Res 2007; 6: 3: 510-521.
22. Миндлин С.З., Соина В.С., Петрова М.А., Горленко Ж.М. Выделение устойчивых к антибиотикам штаммов бактерий из многолетнемерзлых отложений Восточной Сибири. Генетика 2008; 44: 1: 36-44.
23. Brown M.G., Balkwill D.L. Antibiotic resistance in bacteria isolated from the deep terrestrial subsurface. Microb Ecol 2009; 57: 3: 484-493.
24. Brown M.G., Mitchell E.H., Balkwill D.L. Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria. Antimicrob Agents Chemother 2008; 52: 12: 4518-4521.
25. rd Symposium on Antimicrobial Resistance in Animals and the Environment. ARAE. Tour - Vinci, 1-3 june 2009; 118.
26. Sørum H., Sunde M. Resistance to antibiotic in the normal flora of animals. Vet Res 2001; 32: 3-4: 227-241.
27. Tomasz A. Weapons of microbial drug resistance abound in soil flora. Science 2006; 311: 5759: 342-343.
28. Schmitt H., Stoob K., Hamscher G. et al. Tetracycline and tetracycline resistance genes in agricultural soils: microcosm field studies. Microb Ecol 2006; 51: 3: 267-2765.
29. Schmitt H., Greve G., Meisner A. Microcosm studies on the role of manure and antibiotic for resistance development in agricultural soils. ARAE 2009; 55.
30. Chee-Sanford J.C., Aminov P.I., Krapac I.J. et al. Occurrence and diversity of tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities. Appl Environ Microbiol 2001; 67: 41494-1502.
31. Chee-Sanford J.C., Mackie R.I., Koike S. et al. Fate and transport of antibiotic residues and antibiotic resistance genes following land application of manure waste. J Environ Qual 2009; 38: 3: 1086-1108.
32. Alonso A., Sanchez P., Martinez J.L. Environmental selection of antibiotic resistance genes. Environ microbiol 2001; 3: 1: 1-9.
33. Миндлин С.З., Петрова М.А., Басс И.А., Горленко Ж.М. Происхождение, эволюция и миграция генов лекарственной устойчивости. Генетика 2006; 42: 11: 1495-1511.
34. Шестаков С.В. Как происходит и чем лимитируется горизонтальный перенос генов у бактерий. Экол. генетик. 2007; 5: 2: 22-24.
35. Baquero F., Alvarez-Ortega C., Martinez J.L. Ecology and evolution of antibiotic resistance. Environ Microbiol Reports 2009; 1: 6: 469-476.
36. Aminov R.I. The role of antibiotic and antibiotic resistance in nature. Environ Microbiol 2009; 11: 12; 2970-2988.
37. Davies J., Davies D. Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev 2010; 74: 3: 417-433.
38. Звягинцев Д.С., Виноградова К.А., Ефременкова Л.М. Прямое микроскопическое выявление в почве актиномицета - продуцента люминесцирующего антибиотика. Микробиология 1976; 45: 2: 337-341.
39. Degtyareva E.A., Vinogradova K.A., Aleksandrova A.V., Filonenko V.A., Kozhevin P.A. Soil actinomycetes as potencial biofungicides. ISSN 0147-6874. Moscow University Soil Science Bulletin 2009; 64: 2: 73- 77 Allerton Press, Inc.
40. Виноградова К.А., Кожевин П.А. Взаимоотношения актиномицетов с почвенными грибами и их использование для биологического контроля фитопатогенов. Микол. фитопатол. 2011; 45: 4: 289-302.
41. Benveniste R., Davies J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Nat Acad Sci USA 1973; 70: 8: 2276-2280.
42. Piepersberg W., Distler J., Hienzel P., Perez-Gonzales J.A. Antibiotic resistance by modification: many resistance genes could be derived from cellular control genes in actinomycetes. A hypothesis. Actinomycetologica 1988; 2: 83-98.
43. Hon W.C., McKay G.A., Thompson P.R. et al. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases. Cell 1997; 89: 6: 885-695.
44. Wright G.D., Thompson P.R. Aminoglycoside phosphotransferases: proteins, structure, and mechanism. Front Biosci 1999; 4: D9-21.
45. Shaw K.J., Rather P.R., Yare R.S., Miller G.H. Molecular genetics of aminoglycoside resistance genes and familiar relationships of the aminoglycoside-modifying enzymes. Microbiol Rev 1993; 57: 1: 138-163.
46. Heinzel P., Werbitzky O., Distler J., Piepersberg W. A second streptomycin resistance gene from Streptomycesgriseus codes for streptomycin-3’’-phosphotransferase. Relationships between antibiotic and protein kinases. Arch Microbiol 1988; 150: 2: 184-192.
47. Wright G.D., Ladak P. Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium. Antimicrob Agents Chemother 1997; 41: 5: 956-960.
48. Payie K.G., Rather P.N., Clarke A.J. Contribution of gentamicin-2’-acetyltransferase to the O-acetylation of peptidoglycane in Providencia stuartii. J Bacteriol 1995; 177: 15: 4303-4310.
49. Knox J.R., Moews P.C., Frere J.M. Molecular evolution of bacterial beta-lactam resistance. Chem Biol 1996; 3: 11: 937-947.
50. Massova I., Mobashery S. Kinship and diversification of bacterial penicillin-binding proteins and beta-lactamases. Antimicrob Agents Chemother 1998; 42: 1: 1-17.
51. Meroueh S.O., Minasov G., Lee W. et al. Structural aspects for evolution of beta-lactamases from penicillin-binding proteins. J Am Chem Soc 2003; 125: 32: 9612-9618.
52. Poirel L., Kampfer P., Nordmann P. Chromosome-encoded Amber class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases. Antimicrob Agents Chemother 2002; 46: 12: 4038-4040.
53. Daiyasu H., Osaka K, Ishino Y., Toh H. Expansion of the zink metallo-hydrolase family of the beta-lactamase fold. FEBS Lett. 2001; 503: 1: 1-6.
54. Lubelski J., Konings W.N., Driessen A.J. Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria. Microbiol Mol Biol Rev 2007; 71: 3: 463-476.
55. Martinez J.L., Sanchez M., Martinez-Solano L. et al. Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems. FEMS Microbiol Rev 2009; 33: 2: 430-449.
56. Stover C.K., Pham X.Q., Erwin A.L. et al. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature 2000; 406: 6799: 959-964
57. Piddock L.J. Multidrug-resistance efflux pumps: not just for resistance. Nature Rev Microbiol 2006; 4: 8: 629-636.
58. Alonso A., Moralez G., Escalante R. et al. Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology. J Antimicrob Chemoter 2004; 53: 3: 432-434
59. Булгакова В.Г., Орлова Т.И., Полин A.H. Устойчивость актиномицетов-продуцентов к собственным антибиотикам. Антибиотики и химиотер. 2010; 55: 1-2: 42-49.
60. Robicsek A., Jacoby G.A., Hooper D.C. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect Dis 2006; 6: 10: 629-640.
61. Sanchez M.B., Hernandez A., Rodrigues-Martinez J.M. et al. Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophila as a potential source of a novel family of Qnr determinants. BMC Microbiol 2008; 8: 148.
62. Alonso A., Rajo F., Martinez J.L. Environmental and clinical isolates of Pseudomonas aeruginosa show pathogenic and biodegradative properties irrespective of their origin. Environ Microbiol 1999; 1: 5: 421-430.
63. Perichon B., Courvalin P., Galimand M. Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Antimicrob Agents Chemother 2007; 51: 7: 2464-2469.
64. Yamane K., Wachino J., Suzuki S. et al. New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother 2007; 51: 9: 3354-3360.
65. Tran J.N., Jacoby G.A., Hooper D.C. Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase. Antimicrob Agents Chemother 2005; 49: 1: 118-125.
66. Poirel L., Rodriguez-Martinez J.M., Mammeri H. et al. Origin of plasmid-mediated quinolone resistance determinant QnrA. Antimicrob Agents Chemother 2005; 49: 8: 3523-3525.
67. Poirel L., Liard A., Rodriguez-Martinez J.M., Nordmann P. Vibrionaceae as a possible source of Qnr-like quinolone resistance determinants. Antimicrob Agents Chemother 2005; 56: 6: 1118-1121.
68. Hegde S.S., Vetting M.W., Roderick S.L. et al. A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA. Science 2005; 308: 5727: 1480-1483.
69. Pesci E.S., Milbank J.B.J., Pearson J.P. et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc Nat Acad Sci USA 1999; 96: 20: 11229-11234.
70. Baltz R.H. Antibiotic discovery from actinomycetes: will a renaissance follow the decline and fall? SIM News 2005; 55: 186-196.
71. Hall B.G., Barlow M. Evolution of the serine β-lactamases: past, present and future. Drug Resist. Updat. 2004; 7: 2: 111-123.
72. Garau G., Di Guilmi A.M., Hall B.G. Structure-based phylogeny of the metallo-beta-lactamases. Antimicrob Agents Chemother 2005; 49: 7: 2778-2784.
73. Aminov R.I., Garrigues-Jeanjean N., Mackie R.I. Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins. Appl Environ Microbiol 2001; 67: 1-6: 22-32.
74. Kobayashi T., Nonaka L., Maruyama F., Suzuki S. Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria. J Mol Evol 2007; 65: 3: 228-235.
75. Datta N., Hughes V.M. Plasmids of the same Inc groups in Enterobacteria before and after the medical use of antibiotics. Nature 1983; 306: 5943: 616-617.
76. Martinez J.L., Alonso A., Gomez-Gomez J.M., Baquero F. Quinolone resistance by mutations in chromosomal gyrase genes. Just the tip of the iceberg? J Antimicrob Chemother 1998; 42: 6: 683-688.
77. Hooper D.C. Mechanisms of fluoroquinolone resistance. Drug Resist Updat 1999; 2: 1: 38-55.
78. Martinez-Martinez L., Pascual A., Jacoby G.A. Quinolone resistance from a transferable plasmid. Lancet 1998; 351: 9105: 797-799.
79. Heinemann J.A. How antibiotics cause antibiotic resistance. Drug Discov Today 1999; 4: 2: 72-79.
80. Robiscek A., Strahilevitz J., Jacoby G.A. et al. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nature Med 2006; 12: 1: 83-88.
81. Wright M.S., Peltier G.L., Stepanauskas R., McArthur J.V. Bacterial tolerances to metals and antibiotics in metal-contaminated and reference streams. FEMS Microbiol Ecol 2006; 58: 2: 293-302.
82. Pallecchi L., Bartoloni A., Paradisi F., Rossolini J.M. Antibiotic resistance in the absence of antimicrobial use: mechanisms and implications. Expert Rev Anti Infect Ther 2008; 6: 5: 725-732.
83. Zhang L., Kinkelaar D., Huang Y. et al. Acquired antibiotic resistance: are we born with it? Environ Microbiol 2011; 77: 20: 7134-7141.
84. Chait R., Vetsigian K., Kishony R. What counters antibiotic resistance in nature? Nature Chem Biol 2012; 8: 1: 2-5.
85. Knapp C.W., Dolfing J., Ehlert P.A., Graham D.W. Evidence of increasing antibiotic resistance gene abundances in archived soils since 1940. Environ Sci Technol 2010; 44: 2: 580-587.
86. Baquero F., Coque T.M., de la Cruz F. Ecology and evolution as targets: the need for novel eco-evo drugs and strategies to fight antibiotic resistance. Antimicrob Agents Chemother 2011; 55: 8: 3649-3660.
87. Williams J.J., Hergenrother J. Exposing plasmids as the Achilles’ heel of drug-resistant bacteria. Curr Opin Chem Biol 2008; 12: 4.
Рецензия
Для цитирования:
Виноградова К.А., Булгакова В.Г., Полин А.Н., Кожевин П.А. Устойчивость микроорганизмов к антибиотикам: резистома, её объём, разнообразие и развитие. Антибиотики и Химиотерапия. 2013;58(5-6):38-48.
For citation:
Vinogradova K.A., Bulgakova V.G., Polin A.N., Kozhevin P.A. Microbial Antibiotic Resistance:. Antibiot Khimioter = Antibiotics and Chemotherapy. 2013;58(5-6):38-48. (In Russ.)
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