Substances from Pyrolised Tissues of Reptile Carcases Differently Modulate Immunity of Mammals of Both Sexes
Abstract
Substances with gender action on immunity were detected in water soluble hydrolised matter from reptile carcases. The gender action was shown on isolated blood neutrophils, whole blood and in vivo by the antiviral activity on experimental animals, contaminated with three types of viruses: Herpes simplex type 1, the virus of encephalomyocarditis and the virus of hepatitis of mice. The possible mechanism of the inhibitory action on the male immunity was associated with the protein kinase cascade, including protein kinase C, activated by phorbolmyristate in the cells of the immune system.
About the Authors
D. G. Maldov
Sky Co., Ltd., Moscow
Russian Federation
Russian Federation
A. P. Belkov
Sky Co., Ltd., Moscow
Russian Federation
Russian Federation
A. V. Ilyichev
Sky Co., Ltd., Moscow
Russian Federation
Russian Federation
E. I. Astashkin
I.M. Sechenov 1st Moscow State Medical University, Moscow
Russian Federation
Russian Federation
S. S. Grigoryan
N.F. Gamaleya Institute of Microbiology, Epidemiology and Immunology, Moscow
Russian Federation
Russian Federation
V. L. Andronova
D.I. Ivanovsky Institute of Virology, Moscow
Russian Federation
Russian Federation
G. A. Galegov
D.I. Ivanovsky Institute of Virology, Moscow
Russian Federation
Russian Federation
References
1. Татарчук Т.Ф., Чернышов В.П., Исламова А.О. Половые стероидные гормоны и иммунная система. Эндокринная гинекология. Киев: Заповіт 2003; 181-199.
2. Bouman A., Heineman M.J., Faas M.M. Sex hormones and the immune response in humans. Human Reproduction Update 2005; 11: 4: 411-423.
3. Fairweather D., Cihakova D. Alternatively activated macrophages in infection and autoimmunity. J Autoimmun 2009; 33: 3-4: 222-230.
4. Cutolo M., Seriolo B, Villaggio B., Pizzorni C., Craviotto C., Sulli A. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann N Y Acad Sci 2002; 966: 131-142.
5. Reddy J., Waldner H., Zhang X., Illes Z., Wucherpfennig K.W., Sobel R.A., Kuchroo V.K. Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol 2005; 175: 9: 5591-5595.
6. Мальдов Д.Г., Бельков А.П., Ильичев А.В., Асташкин Е.И. Влияние комплексного гидрофильного низкомолекулярного препарата «Стимфорте» на функциональную активность фагоцитов крови человека. Иммунология 2009; 2: 95-97.
7. Rubtsova K., Marrack P., Rubtsov A.V. Age-associated B cells: are they the key to understanding why autoimmune diseases are more prevalent in women? Expert Rev Clin Immunol 2012; 8: 1: 5-7.
8. Андронова В.Л., Гроховский С.Л., Суровая А.Н., Гурский Г.В., Галегов Г.А. Действие димерных производных нетропсина и их комбинаций с ацикловиром на герпесвирусную инфекцию мышей. Доклады Академии Наук, 2007; 413: 6: 1-5.
9. Calippe B., Douin-Echinard V., Delpy L., Laffargue M., Lelu K., Krust A., Pipy B., Bayard F., Arnal J.F., Guery J.C., Gourdy P. 17-Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signalling in macrophages in vivo. J Immunol 2010; 185: 2: 1169-1176.
10. Rubtsov A.V., Rubtsova K., Kappler J.W., Marrack P. Genetic and hormonal factors in female-biased autoimmunity. Autoimmun Rev 2010; 9: 7: 494-498.
11. Newell S.W., Perchellet E.M., Gao X.M., Chen G., Perchellet J.P. Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo. Cancer Lett 1996; 98: 2: 241-251.
Review
For citations:
Maldov D.G., Belkov A.P., Ilyichev A.V., Astashkin E.I., Grigoryan S.S., Andronova V.L., Galegov G.A. Substances from Pyrolised Tissues of Reptile Carcases Differently Modulate Immunity of Mammals of Both Sexes. Antibiot Khimioter = Antibiotics and Chemotherapy. 2014;59(3-4):16-21. (In Russ.)
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