Structural characteristics of ibuprofen substances manufactured by different firms and the impact of micronization on them were compared. The study showed that the use of X-ray diffraction methods was necessary for certification of medicinal (crystalline) since only such methods provided information on the substance crystal structure, the molecular state and polymorphous forms.

The efficacy of cycloferon in complex therapy of salmonellosis and yersiniosis in children (n=220) was investigated under clinical and laboratory conditious. It was shown, that cycloferon had direct and indirect immunotropic action in salmonellosis and yersiniosis in children. In contrast to the conventional antibiotic therapy, the use of cycloferon provided a more rapid relief of the local and systemic symptoms, reduction of superinfection or exacerbation. It had a positive effect on the antiinfective resistance of the colon mucosa resulting in normalization of the colon lumen microecology. The use of cycloferon provided eradication of the pathogen and opportunistic organisms. In the treatment of salmonellosis it enhanced formation of rare bacterial reconvalescent Shigella.

The results of the microbiological diagnosis of infective inflammatory complications in patients with iatrogenic esophageotracheal fistula and the tactics of their antibacterial prophylaxis and therapy within a 9-year observation period (2003-2011) were analysed. The main organisms colonizing the tracheobronchial tree in the patients were S.epidermidis, S.aureus, enteric bacteria, P.aeruginosa and Candida. An increase of the S.epidermidis resistance to rifampicin, moxifloxacin and especially ciprofloxacin was observed. The resistance of S.aureus did not significantly change. Within the observation period, high susceptibility of all the Staphylococcus isolates to vancomycin and linezolid remained stable. Among the nonfermenting gramnegative bacteria, the P.aeruginosa isolates were the most frequent and characterized by a lower portion of the isolates with preserved susceptibility to the agents (except polymyxin B) known earlier as antipyocyanic antibiotics, i.e. to imipenem and cefepim. Since the proportion of P.aeruginosa in the etiology of pyoinflammatory processes in the region of esophageotracheal fistula ranged within 9.3 to 17.5%, the fact should be considered in the antibiotic therapy. There was observed an increase in the frequency of infectious complications due to other nonfermenting gramnegative bacteria (acinetobacters) and first of all A.baumannii. Various Candida isolates were characterized by dependence of the susceptibility on the selective pressure of nonrational therapy, as well as their species (the presence of such species as C.Krusei and C.glabrata with natural resistance), that required not only the species identification but also determination of the Candida isolates resistance in every particular case.

The prospective randomized study involved 60 patients with chronic dystrophic diseases of the vulva. The clinical efficacy of cycloferon in the complex treatment of the patients and its on the psychological and functional state and the dynamics of the life quality were investigation.

Seventy five patients with urogenital chlamydial and mycoplasmic infections were enrolled in the trial. In the etiotropic therapy azithromycin was used in the standard dosage (1.0-1.5 g) depending on the infection. The treatment with azithromycin, in addition to the high eradication rates, was also evident of its effect on the cytokine levels in the patients, that was characteristic of a significant increase of the IFN-γ level and a decrease of the IL-β and IL-6 levels in the blood.

Criteria of tigecycline (Tygacil) use for the treatment surgical infections in oncologic in patients were developed. High efficacy of tigecycline in vitro and in vivo against multiresistant hospital strains persistent in the surgical department of the gastrointestinal oncologic division.

The results of 3-year experience with voriconasole in oncologic practice are presented. Rational schemes for the use of caspofungin and mycofungin in the treatment of oncologic in patients and the criteria of their use in the thersapy of fungal nosocomial infections were developmed. Good clinical and microbiological efficacy of caspofungin and mycofungin against Candida non-albicans was shown.

Prosthetic joints infection in after is a serious medical, social and financial problem. Significant achievements in prophylaxis of such infections are well known. In cases of primary endoprosthetics of large joints, the frequency of infection in the leading world clinics is 0.5-2%. However, the approaches to the treatment of such infections are different especially with respect to the antibacterial therapy: choice of drugs, administration routes, treatment course and discontinuation. Under conditions of global growth of resistance in nosocomial pathogens, the choice of antimicrobials requires consideration not only of the formal susceptibility criteria, but also of the pharmacokinetic and pharmacodynamic indices.