Alternative Therapeutic Potential of Antibiotics Inhibiting Bacterial Translation as Regulators of Mitochondrial Dysfunction
https://doi.org/10.37489/0235-2990-2025-70-7-8-74-91
EDN: WMUGXT
Abstract
Antibiotics, which evolved as a chemical weapon of some bacteria against others, are primarily known for their microbicidal and/or bacteriostatic effects; however, they also have numerous pleiotropic effects: anti-amyloid, anti-inflammatory, antioxidant, and anti-apoptotic. This review considers antibiotics with a translation-inhibiting mechanism of action, primarily tetracyclines, in the context of their non-antibiotic biological aspect, namely, the possibilities of supportive therapy for neurodegenerative diseases, as well as their antimitochondrial action and the mediated effect of aging cancellation.
About the Authors
O. V. Kisil
Gause Institute of New Antibiotics
Russian Federation
Competing Interests:
Russian Federation
Olga V. Kisil — Ph. D. in Chemistry, Scientific Secretary.
Moscow
Competing Interests:
The authors declare that there is no conflict of interest related to the publication of this article
M. I. Zvereva
Lomonosov Moscow State University
Russian Federation
Competing Interests:
Russian Federation
Maria I. Zvereva — D. Sc. in Chemistry, Professor, Department of Chemistry of Natural Compounds, Faculty of Chemistry.
Moscow
Competing Interests:
The authors declare that there is no conflict of interest related to the publication of this article
E. I. Olsufyeva
Gause Institute of New Antibiotics
Russian Federation
Competing Interests:
Russian Federation
Evgeniya N. Olsufyeva — D. Sc. in Chemistry, Professor, Chief Researcher. Gause Institute of New Antibiotics
Moscow
Competing Interests:
The authors declare that there is no conflict of interest related to the publication of this article
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Kisil OV, Zvereva MI, Olsufyeva EI. Alternative Therapeutic Potential of Antibiotics Inhibiting Bacterial Translation as Regulators of Mitochondrial Dysfunction. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2025;70(7-8):74-91. (In Russ.) https://doi.org/10.37489/0235-2990-2025-70-7-8-74-91. EDN: WMUGXT
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