Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity
Abstract
A highly potent strain of Lentinus edodes producing lentinomycin B, an erythadenin metabolite showing hypolipidemic activity, and biologically active water soluble endopolysaccharides was isolated. The optimum composition of the medium for the strain submerged cultivation was developed. The medium provided shorter period of the strain cultivation and a 2-fold increase of the biomass yield and production of the endopolysaccharides up to 21 g/l and 4.8 g/l of the culture fluid respectively. The total fraction of the water soluble polysaccharides isolated from the mycelium contained glucose, galactose, mannose, arabinose and xylose as the neutral monosaccharides. Glucose was the main monosaccharide. The procedure of the strain submerged cultivation provided production of several final substances during a single technological cycle.
About the Authors
L. M. Krasnopolskaya
G. F. Gause Research Institute of New Antibiotics, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
N. Yu. Kats
G. F. Gause Research Institute of New Antibiotics, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
A. I. Usov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Barkov
G. F. Gause Research Institute of New Antibiotics, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
V. A. Vinokurov
I. M. Gubkin Russian State University of Petroleum and Gases
Russian Federation
Russian Federation
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Review
For citations:
Krasnopolskaya L.M., Kats N.Yu., Usov A.I., Barkov A.V., Vinokurov V.A. Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity. Antibiot Khimioter = Antibiotics and Chemotherapy. 2012;57(9-10):3-7. (In Russ.)
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