SCCmec кассеты, эволюция и генетические линии метициллинорезистентных золотистых стафилококков
Аннотация
Метициллинорезистентные золотистые стафилококки (MRSA) являются важнейшими возбудителями внутрибольничных и внебольничных инфекций. Метициллинорезистентность обусловлена наличием гена mecA, который локализован в сложноорганизованном мобильном элементе - стафилококковой хромосомной кассете (staphylococcal cassette chromosome mec - SCCmec). Стафилококковые кассеты имеют различное строение, и на сегодняшний день описано одиннадцать типов. Кассеты SCCmec I-IV типов всегда ассоциированы с эпидемиологически значимыми генетическими линиями стафилококков. Так, пандемично распространённые госпитальные штаммы MRSA (hospital-associated methicillin-resistant Staphylococcus aureus HA-MRSA), принадлежащие к клональным комплексам CC5, CC8, имеют SCCmec I-III типов. Распространение во многих регионах мира вирулентных внебольничных MRSA (community-associated methicillin-resistant Staphylococcus aureus CA-MRSA), в первую очередь, связывают с особенностями строения SCCmec IV типа, а также наличием недавно описанного мобильного элемента катаболизма аргинина (ACME), повышающего колонизационную активность стафилококков. В обзоре представлены современные данные о происхождении, генетическом строении, классификации SCCmec. Описаны глобальные генетические лини MRSA, а также рассмотрена проблема CA-MRSA.
Об авторах
В. В. Гостев
ФГБУ «НИИ Детских инфекций» ФМБА России
Россия
Россия
С. В. Сидоренко
ФГБУ «НИИ Детских инфекций» ФМБА России
Россия
Россия
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Рецензия
Для цитирования:
Гостев В.В., Сидоренко С.В. SCCmec кассеты, эволюция и генетические линии метициллинорезистентных золотистых стафилококков. Антибиотики и Химиотерапия. 2012;57(9-10):38-46.
For citation:
Gostev V.V., Sidorenko S.V. Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureus. Antibiot Khimioter = Antibiotics and Chemotherapy. 2012;57(9-10):38-46. (In Russ.)
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