Eye infection is one of the temporary invalidity causes that can lead to blindness. The former antibacterial components of eye drops were polyhexamethylene guanidine hydrochloride and polyhexamethylene guanidine phosphate. Polyhexamethylene guanidine in the form of form of succinate with preserved activity and lover toxicity is described. The antibacterial activity spectra of polyhexamethylene guanidine succinate and polyhexamethylene guanidine hydrochloride were comparatively estimated.

European recommendations for eradication of Helicobacter pylori are presented. The increase of the resistance to clarithromycin requires the necessity of rational use of quadritherapy as the first line treatment and sequential therapy including drugs active against the pathogen with low resistance. New treatment regiments for patients with allergy to penicillin are recommended.

The efficacy of reamberin, remaxol, S-adenosyl-L-methionine (ademethionine) and 5% glucose solution was estimated in the treatment of patients with tuberculosis of the respiratory organs and drug hepatotoxicity signs confirmed by higher activity of liver indicative enzymes and nitrogen oxide levels. Remaxol showed a pronounced positive effect on the cytolytic syndrome signs, evident from lower activity of alanine aminotransferase and aspartate aminotransferase. At the same time ademethionine was superior to remaxol in the effect on the cholestatic signs and inferior in the effect on the cytolytic signs. By the effect on the activity of alanine aminotransferase and aspartate aminotransferase, reamberin was inferior to remaxol and superior to ademethionine, its effect on the cholestasis markers level vs. the other drugs being superior only to that of 5% glucose solution. As compared to reamberin, ademethionine and 5% glucose solution, remaxol promoted higher integral indices of the host antioxidant protection (total antioxidant capacity and total antioxidant status), that partially explained the drug pronounced hepatoprotective effect.

The vaginal discharge is one of the most frequent symptoms requiring medical advise. Vaginal discharges are mainly associated with three diseases: bacterial vaginosis, trichomononiasis and candidiasis. The review is concerned with up-to-date approaches to the treatment of females with bacterial vaginosis and trichomononiasis, diseases different by the etiology and pathogenesis, but at the same time similar with respect to the treatment. The analysis is in compliance with the principles of the two fundamental world guidelines.

The review deals with recurrent respiratory diseases in children. The concept of frequently ill children is characterized and the properties of the pathogens are described. The factors promoting development of recurrent respiratory diseases, including hereditary predisposition (mother health condition) are indicated and the genetic determination of the recurrent diseases associated with the blood group is shown. Development of immune dysbalance evident of changes in the cellular humoral immune response and in the factors of nonspecific resistance, that characterize changes in the local immunity in such children leading to chronic pathologic processes, is concerned. The effect of the atopic conditions and allergic diseases on the severity of respiratory pathology is stated. Interaction and mechanisms of development of neuroendocrine and immune systems are described. Cycloferon is shown to be useful in correction of impaired immune resistance in frequently ill children that promotes less frequent episodes and shorter terms of recurrent acute respiratory diseases per year.

The problem of prophylaxis and therapy of influenza infections remains one of the priority goals for medical science and practical health care. The review includes the discussion of antiviral activity of Deitiforine, a Russian chemotherapeutic. The data on the toxicity and the specific activity spectrum in cell cultures, chicken embryos and laboratory animals are presented. The problem of the influenza viruses resistance to cage compounds and in particular to rimantadine and Deitiforine is also discussed.